TISSUE CULTURES OF MOUSE PERITONEAL EXUDATES INOCULATED WITH BLASTOMYCES DERMATITIDIS
نویسندگان
چکیده
منابع مشابه
Tissue cultures of mouse peritoneal exudates inoculated with Blastomyces dermatitidis.
Observations on mouse monocytes, maintained in cell culture and inoculated with Histoplasma capsulatum, have been previously reported (Howard, 1959). H. capsulatum differs from other fungi pathogenic for man in that it is primarily a parasite of cells of the reticulo-endothelial system. Thus the fungus was ideally suited to preliminary studies on the usefulness of tissue culture techniques for ...
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Cell-mediated immunity plays the dominant role in the immune response of mice to Blastomyces dermatitidis infections. Since macrophages play an important role in cell-mediated immunity, the interactions between sensitized murine peritoneal macrophages and the yeast phase of B. dermatitidis were investigated. Scanning electron microscopy showed that the sensitized macrophages readily phagocytize...
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The inhalation of conidia of Blastomyces dermatitidis, a fungus found in soil, causes disease in humans and animals. We studied the genetic diversity of this pathogen by extracting DNA yeasts and analyzing them with a polymerase chain reaction (PCR)-based typing system we developed, which used restriction fragment analysis of amplicons from the regions between the rDNA repeats and allowed us to...
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Blastomyces dermatitidis, a dimorphic fungus and the causative agent of blastomycosis, is widely considered an extracellular pathogen, with little evidence for a facultative intracellular lifestyle. We infected mice with spores, that is, the infectious particle, via the pulmonary route and studied intracellular residence, transition to pathogenic yeast, and replication inside lung cells. Nearly...
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This study reports a case of Blastomyces dermatitidis soft tissue infection resulting in a disfiguring lower eyelid ectropion from cicatricial and postinflammatory cutaneous changes. Primary treatment included intravenous amphotericin B followed by long-term oral itraconazole, which resulted in complete remission of the disease without debridement, after which cicatricial ectropion was repaired...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1960
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.80.4.522-527.1960